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EP-2084: Risk assessment of secondary cancer after craniospinal radiotherapy in childhood medulloblastoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Giugliano, Francesca Maria Mascarin, Maurizio Iadanza, Luciano Coassin, Elisa Drigo, Annalisa Trovò, Marco |
| Copyright Year | 2016 |
| Abstract | Results: When comparing dosimetric endpoints four treatment techniques without the inclusion of FFF, IMRT performed statistically better 2cc PTV maximum, 2cc body maximum and homogeneity index for the PTV compared to all other techniques. In general Organs at Risk (OAR) constraints were comparable between the conventional tangents, Field in field and hybrid IMRT techniques. VMAT performed statistically worse in several endpoints including both the point maximum and mean dose for the contralateral breast, Volume receiving 10Gy (V10) and 5Gy (V5) for the heart, ipsilateral and contralateral lung V5 and mean dose as well as the mean dose for combined lung compared to all other techniques planned. There was no statistical difference for the V20 for the ipsilateral lung and combined lung for all techniques. When looking at the beam on time Hybrid IMRT(10.21s) had the quickest and VMAT(48.76s) the longest. When comparing dosimetric endpoints four treatment techniques with the inclusion of FFF hybrid IMRT and FFF Hybrid IMRT performed statistically better for PTV2cc max, PTV homogeneity index, total body max and 2cc max. For all other OAR parameters tested in the investigated modulated techniques, treatment planning with FFF beams resulted in plans of equal quality compared with flattened beams. No significant differences were found. When looking at the beam on time FFF Hybrid IMRT(7.45s) had the quickest compared to current tangential delivery times (20.59s). |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0167-8140(16)33335-7 |
| Volume Number | 119 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82165731.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S0167-8140%2816%2933335-7 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
