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A double-blind placebo-controlled randomised trial of omega-3 supplementation in children with moderate ADHD symptoms
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cornu, Catherine Mercier, Catherine Ginhoux, Tiphanie Masson, Sandrine Mouchet, Julie Nony, Patrice Kassai, Behrouz Laudy, Valérie Berquin, Patrick Franc, Nathalie Heuzey, Marie-France Le Desombre, Hugues Revol, Olivier |
| Copyright Year | 2017 |
| Abstract | ObjectiveClinical trials and inconclusive meta-analyses have investigated the effects of omega-3 supplements in children with Attention-Deficit Hyperactivity Disorder (ADHD). We performed a randomised placebo-controlled trial to evaluate the efficacy of omega-3 fatty acids.MethodsChildren aged 6–15 years with established diagnosis of ADHD were randomised 1:1 to receive either supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or a placebo for 3 months. Psychotropic or omega-3-containing treatments were not authorised during the study. The primary outcome was the change in the Attention-Deficit Hyperactivity Disorder Rating Scale version 4 (ADHD-RS-IV). Other outcomes included safety, lexical level (Alouette test), attention (Test of Attentional Performance for Children—KiTAP), anxiety (48-item Conners Parent Rating Scale-Revised—CPRS-R), and depression (Children’s Depression Inventory—CDI).ResultsBetween 2009 and 2011, 162 children were included in five French child psychiatry centres. The mean age was 9.90 (SD 2.62) years and 78.4% were boys. The inclusion ADHD-RS-IV at was 37.31 (SD 8.40). The total ADHD-RS-IV score reduction was greater in the placebo group than in the DHA–EPA group: −19 (−26, −12) % and −9.7 (−16.6, −2.9) %, respectively, p = 0.039. The other components of the Conners score had a similar variation but the differences between groups were not significant. Two patients in the DHA–EPA group and none in the placebo group experienced a severe adverse event (hospitalisation for worsening ADHD symptoms).ConclusionThis study did not show any beneficial effect of omega-3 supplement in children with mild ADHD symptoms. |
| Starting Page | 377 |
| Ending Page | 384 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s00787-017-1058-z |
| Alternate Webpage(s) | https://www.adhd-federation.org/fileadmin/user_upload/Abstract_Review/2018/07_July/Treatment/A_double-blind_placebo-controlled_randomised_trial_of_omega-3_supplementation_in_children_with_moderate_ADHD_symptoms.pdf |
| PubMed reference number | 28993963 |
| Alternate Webpage(s) | https://doi.org/10.1007/s00787-017-1058-z |
| Journal | Medline |
| Volume Number | 27 |
| Journal | European Child & Adolescent Psychiatry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
