NDLI: Clinical significance of platelet-derived growth factor receptor-β gene expression in stage II/III gastric cancer with S-1 adjuvant chemotherapy.

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Clinical significance of platelet-derived growth factor receptor-β gene expression in stage II/III gastric cancer with S-1 adjuvant chemotherapy.

Content Provider	Semantic Scholar
Author	Higuchi, Akio Oshima, Takashi Yoshihara, Kazue Sakamaki, Kentaro Aoyama, Toru Suganuma, Nobuyasu Yamamoto, Naoto Sato, Tsutomu Cho, Haruhiko Shiozawa, Manabu Yoshikawa, Takaki Rino, Yasushi Kunisaki, Chikara Imada, Toshio Masuda, Munetaka
Copyright Year	2017
Abstract	Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative surgery and adjuvant chemotherapy. Platelet-derived growth factor receptor-β (PDGFR-β) is associated with the proliferation of cancer cells. The present study therefore investigated the association of PDGFR-β gene expression with patient outcome in 134 stage II/III gastric cancer patients who received adjuvant chemotherapy with S-1. Relative PDGFR-β gene expression was measured in surgical cancer tissue and adjacent normal mucosa specimens by reverse transcription-quantitative polymerase chain reaction. The PDGFR-β gene expression levels were found to be significantly higher in the cancer tissues compared with the adjacent normal mucosa. A high level of PDGFR-β gene expression was associated with a significantly poorer 5-year overall survival rate compared with a low level of PDGFR-β expression. Upon multivariate analysis, PDGFR-β gene expression was found to be an independent predictor of survival. Overall, the study indicates that PDGFR-β overexpression in gastric cancer tissues is a useful independent predictor of outcome in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
Starting Page	905
Ending Page	911
Page Count	7
File Format	PDF HTM / HTML
DOI	10.3892/ol.2016.5494
PubMed reference number	28356977
Journal	Medline
Volume Number	13
Issue Number	2
Alternate Webpage(s)	https://www.spandidos-publications.com/ol/13/2/905/download
Alternate Webpage(s)	https://doi.org/10.3892/ol.2016.5494
Journal	Oncology letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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