NDLI: Prognostic significance of heat shock protein 105 in lung adenocarcinoma.

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Prognostic significance of heat shock protein 105 in lung adenocarcinoma.

Content Provider	Semantic Scholar
Author	Oda, Tomofumi Morii, Eiich Inoue, Masayoshi Ikeda, Jun-ichiro Aozasa, Katsuyuki Okumura, Meinoishin
Copyright Year	2009
Abstract	Heat shock protein 105 (HSP105) is overexpressed in various tumors and is known to protect cells from cytotoxic stimuli. The prognostic significance of HSP105 expression in cancer has not been fully evaluated. Here, HSP105 expression in lung adenocarcinoma was immunohistochemically examined in 116 patients: 68 males and 48 females with ages ranging from 38-81 (median 63) years. Tumor stage was I in 64, II in 16 and III in 36 patients. In non-cancerous tissues, HSP105 was expressed in the ciliated cells of bronchi. Tumor cells were constantly positive for HSP105, with varying intensities. The HSP105 score in each case was determined based on the staining intensity of the tumor cells occupying the widest area of cancerous tissue as follows: cases with tumor cells showing an intensity weaker than, comparable to and stronger than the bronchial epithelium were assigned a score of 1, 2 and 3, and numbered 84, 19 and 13 cases, respectively. HSP105 score was significantly correlated with the rate of recurrence and the stage of the disease. Univariate analysis showed that lymph node metastasis, disease stage and HSP105 score were unfavorable prognostic factors. Multivariate analysis revealed that lymph node metastasis and HSP105 score were independent prognostic factors for overall and disease-free survival. HSP105 expression is useful for the prediction of prognosis in patients with lung adenocarcinoma.
Starting Page	2
Ending Page	11
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/mmr/2/4/603/download
PubMed reference number	21475873v1
Alternate Webpage(s)	https://doi.org/10.3892/mmr_00000144
DOI	10.3892/mmr_00000144
Journal	Molecular medicine reports
Volume Number	2
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	Adenocarcinoma of lung (disorder) Anatomic Node Biomarkers, Tumor Body tissue Bronchi Epithelium of bronchus Forecast of outcome HSP72 Heat-Shock Proteins HSPH1 wt Allele Heat shock proteins Heat-Shock Response Neoplasms Patients PersonNameUse - assigned Staining Intensity Staining method lymph node metastases lymph nodes
Content Type	Text
Resource Type	Article

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