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Anti-inflammatory Effect of an Ethanolic Extract of Myagropsis yendoi in Lipopolysaccharide-Stimulated BV-2 Microglia Cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Salih, Sarmad Ali Kim, Hyeung-Rak |
| Copyright Year | 2014 |
| Abstract | Abstract Marine brown algae have been identified as a rich source of structurally diverse bioactive compounds. Whether Myagropsis yendoi ethanolic extracts (MYE) inhibit inflammatory responses was investigated using lipopolysaccharide (LPS)-stimulated microglia BV-2 cells. MYE inhibited LPS-induced nitric oxide (NO) production in a dose-dependent manner and suppressed the expres-sion of inducible nitric oxide synthase in BV-2 cells. MYE also reduced the production of pro-inflammatory cytokines in LPS-stimulated BV-2 cells. LPS-induced nuclear factor-κB (NF-κB) transcriptional activity and NF-κB translocation into the nucleus were significantly inhibited by MYE treatment through preventing degradation of the inhibitor κB-α. Moreover, MYE inhibited the phosphorylation of AKT, ERK, JNK, and p38 mitogen-activated protein kinase in LPS-stimulated BV-2 cells. These results indicate that MYE is a potential source of therapeutic or functional agents for neuroinflammatory diseases. Key words: Anti-neuroinflammation, |
| Starting Page | 27 |
| Ending Page | 35 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.5657/FAS.2014.0027 |
| Volume Number | 17 |
| Alternate Webpage(s) | http://www.e-fas.org/Upload/files/E-FAS/04_%EA%B9%80%ED%98%95%EB%9D%BD.pdf |
| Alternate Webpage(s) | http://ocean.kisti.re.kr/downfile/volume/kofis/E1HKAL/2014/v17n1/E1HKAL_2014_v17n1_27.pdf |
| Alternate Webpage(s) | https://doi.org/10.5657/FAS.2014.0027 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
