NDLI: Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.

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Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.

Content Provider	Semantic Scholar
Author	Scholz, Joachim E. Broom, Daniel C. Youn, Dong-Ho Mills, Charles D. Kohno, Tatsuro Suter, Marc René Moore, Kimberly A. Décosterd, Isabelle Coggeshall, Richard E. Woolf, Clifford J.
Copyright Year	2005
Abstract	We show that transsynaptic apoptosis is induced in the superficial dorsal horn (laminas I-III) of the spinal cord by three distinct partial peripheral nerve lesions: spared nerve injury, chronic constriction, and spinal nerve ligation. Ongoing activity in primary afferents of the injured nerve and glutamatergic transmission cause a caspase-dependent degeneration of dorsal horn neurons that is slow in onset and persists for several weeks. Four weeks after spared nerve injury, the cumulative loss of dorsal horn neurons, determined by stereological analysis, is >20%. GABAergic inhibitory interneurons are among the neurons lost, and a marked decrease in inhibitory postsynaptic currents of lamina II neurons coincides with the induction of apoptosis. Blocking apoptosis with the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD) prevents the loss of GABAergic interneurons and the reduction of inhibitory currents. Partial peripheral nerve injury results in pain-like behavioral changes characterized by hypersensitivity to tactile or cold stimuli. Treatment with zVAD, which has no intrinsic analgesic properties, attenuates this neuropathic pain-like syndrome. Preventing nerve injury-induced apoptosis of dorsal horn neurons by blocking caspase activity maintains inhibitory transmission in lamina II and reduces pain hypersensitivity.
File Format	PDF HTM / HTML
DOI	10.1523/JNEUROSCI.1526-05.2005
PubMed reference number	16093381
Journal	Medline
Volume Number	25
Issue Number	32
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/25/32/0.2.full.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/25/32/7317.full.pdf
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.1526-05.2005
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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