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Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Burik, Jo-Anne H. Van Ratanatharathorn, Voravit Stepan, Daniel E. Miller, Carole B. Lipton, Jeffrey Howard Vesole, David H. Bunin, Nancy J. Wall, Donna Hiemenz, John W. Satoi, Yoichi Lee, Jeannette Jen-Mai Walsh, Thomas J. |
| Copyright Year | 2004 |
| Abstract | We hypothesized that chemoprophylaxis with the echinocandin micafungin would be an effective agent for antifungal prophylaxis during neutropenia in patients undergoing hematopoietic stem cell transplantation (HSCT). We therefore conducted a randomized, double-blind, multi-institutional, comparative phase III trial, involving 882 adult and pediatric patients, of 50 mg of micafungin (1 mg/kg for patients weighing <50 kg) and 400 mg of fluconazole (8 mg/kg for patients weighing <50 kg) administered once per day. Success was defined as the absence of suspected, proven, or probable invasive fungal infection (IFI) through the end of therapy and as the absence of proven or probable IFI through the end of the 4-week period after treatment. The overall efficacy of micafungin was superior to that of fluconazole as antifungal prophylaxis during the neutropenic phase after HSCT (80.0% in the micafungin arm vs. 73.5% in the fluconazole arm [difference, 6.5%]; 95% confidence interval, 0.9%-12%; P=.03). This randomized trial demonstrates the efficacy of an echinocandin for antifungal prophylaxis in neutropenic patients. |
| Starting Page | 87 |
| Ending Page | 91 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://theebmproject.files.wordpress.com/2014/09/micafungin-vs-fluconazole-for-prophylaxis-during-neutropenia-in-the-setting-of-hsct.pdf |
| PubMed reference number | 15546073v1 |
| Volume Number | 39 |
| Issue Number | 10 |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antifungal Agents Cell Transplantation Chemoprevention Confidence Intervals Echinocandins Fluconazole Hematopoietic stem cells Hemopoietic stem cell transplant Invasive Fungal Infections Mycoses Neutropenia Numerous Patients Probability mg/kg micafungin |
| Content Type | Text |
| Resource Type | Article |
