Loading...
Please wait, while we are loading the content...
Similar Documents
Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Poirel, Laurent Héritier, Claire Nordmann, Patrice L. |
| Copyright Year | 2004 |
| Abstract | A chromosome-encoded beta-lactamase gene from a Shewanella oneidensis reference strain was cloned and expressed in Escherichia coli. It encoded a carbapenem-hydrolyzing Ambler class D beta-lactamase, OXA-54, that shared 92% amino acid identity with the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 from Klebsiella pneumoniae. This work suggests that Shewanella spp. may produce the progenitor of oxacillinases compromising the efficacy of imipenem in clinically relevant gram-negative pathogens. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://aac.asm.org/content/48/1/348.full.pdf |
| PubMed reference number | 14693565v1 |
| Volume Number | 48 |
| Issue Number | 1 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Bacteria, Aerobic Carbapenems Clone Cells Genes, vif Imipenem Integrase Integrons Klebsiella pneumoniae Pneumonia Shewanella Tyrosine beta-Lactamase gram oxacillinase recombinase |
| Content Type | Text |
| Resource Type | Article |
