Gray and White Matter Changes in Subjective Cognitive Impairment, Amnestic Mild Cognitive Impairment and Alzheimer's Disease: A Voxel-Based Analysis Study

Content Provider	Semantic Scholar
Author	Kiuchi, Kuniaki Kitamura, Soichiro Taoka, Toshiaki Yasuno, Fumihiko Tanimura, Masami Matsuoka, Kiwamu Ikawa, Daisuke Toritsuka, Michihiro Hashimoto, Kazumichi Makinodan, Manabu Kosaka, Jun Morikawa, Masayuki Kichikawa, Kimihiko Kishimoto, Toshifumi
Copyright Year	2014
Abstract	Subjective cognitive impairment may be a very early at-risk period of the continuum of dementia. However, it is difficult to discriminate at-risk states from normal aging. Thus, detection of the early pathological changes in the subjective cognitive impairment period is needed. To elucidate these changes, we employed diffusion tensor imaging and volumetry analysis, and compared subjective cognitive impairment with normal, mild cognitive impairment and Alzheimer's disease. The subjects in this study were 39 Alzheimer's disease, 43 mild cognitive impairment, 28 subjective cognitive impairment and 41 normal controls. There were no statistically significant differences between the normal control and subjective cognitive impairment groups in all measures. Alzheimer's disease and mild cognitive impairment had the same extent of brain atrophy and diffusion changes. These results are consistent with the hypothetical model of the dynamic biomarkers of Alzheimer's disease.
File Format	PDF HTM / HTML
DOI	10.1371/journal.pone.0104007
PubMed reference number	25093415
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/69/61/pone.0104007.PMC4122459.pdf
Alternate Webpage(s)	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104007&type=printable
Alternate Webpage(s)	https://doi.org/10.1371/journal.pone.0104007
Journal	PloS one
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article