NDLI: Study of Serum Malondialdehyde and Whole Blood Reduced Glutathione in Emphysema Patients *

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Study of Serum Malondialdehyde and Whole Blood Reduced Glutathione in Emphysema Patients *

Content Provider	Semantic Scholar
Author	Rajesh, Chouhan
Copyright Year	2013
Abstract	Background: Emphysema is associated with high incidence of morbidity and mortality. The imbalance between oxidants and antioxidants is thought to play an important role in the pathogenesis of Emphysema. Methods: A total number of 80 subjects comprising of 40 healthy controls and 40 Emphysema cases were studied. In all the subjects, serum levels of malondialdehyde (MDA) as a biomarker of lipid peroxidation and antioxidant whole blood reduced glutathione (GSH) were estimated. Results: The level of whole blood reduced glutathione was significantly decreased in emphysema patients when compared to controls. Serum MDA was significantly increased in Emphysema patients when compared to controls. Conclusion: The presence of increased systemic oxidative stress in emphysema patients seems to be associated with current active smoking and systemic inflammation. The decrease in antioxidants levels appears to be mainly a consequence of increased oxidative stress. This suggests that oxidative stress is likely to be involved in pathogenesis of emphysema.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ejmanager.com/mnstemps/38/38-1366530930.pdf
Language	English
Access Restriction	Open
Subject Keyword	3,4-Methylenedioxyamphetamine Antioxidants Biological Markers Eighty Glutathione Incidence matrix Inflammation Lipid Peroxidation Lupus Erythematosus, Systemic Malondialdehyde Morbidity - disease rate Oxidants Oxidative Stress Patients Pulmonary Emphysema Smoke
Content Type	Text
Resource Type	Article

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