Elevated total plasma homocysteine levels are associated with type 2 diabetes in women with hypertension.

Content Provider	Semantic Scholar
Author	Wang, Changyi Wu, Qunhong Zhang, Lina Hao, Yanhua Fan, Rui Peng, Xiaolin Liu, Shengyuan Chen, Zhongwei Zhang, Tong Chen, Sihan Ma, Jian-ping Duan, Shiwei Han, Liyuan
Copyright Year	2015
Abstract	BACKGROUND AND OBJECTIVES There is only limited available evidence of a relationship between total plasma homocysteine (tHcy) levels and type 2 diabetes in hypertensive subjects. METHODS AND STUDY DESIGN A total of 5,935 Chinese essentially hypertensive subjects were recruited by cluster sampling from 60 communities. The cases had diabetes, whereas the controls did not. Anthropometric indices and biochemical parameters were assessed using standard procedures. A multivariable analysis was performed to analyze the association of tHcy and type 2 diabetes susceptibility in hypertensive subjects. RESULTS The 5,241 controls (women/men: 2,716/2,625) and 594 cases (women/men: 291/303) were recruited consecutively. The level of tHcy was dose- dependently associated with type 2 diabetes in the hypertensive women subjects. After controlling for corresponding confounding factors, a significant trend was only noted in the women subjects, with odds ratios per 5 μmol/L tHcy of 1.11 (95% confidence interval (CI), 1.07-1.16) in the crude model, 1.05 (95% CI, 1.01-1.11) in model 1, and 1.07 (95% CI, 1.02-1.13) in model 2. However, no significant result was found for levels of tHcy>or=15 μmol/L vs <15 μmol/L in the men, women and all hypertensive subjects. CONCLUSIONS When the level of tHcy was divided into quartiles, tHcy was positively associated with type 2 diabetes in hypertensive women subjects. However, when the level of tHcy was separated into hyperhomocysteinemic (>or=15 μmol/L) and normal (<15 μmol/L), no significant results were observed.
Starting Page	99
Ending Page	101
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.apjcn.org/update/pdf/2015/4/2014-0190/2014-0190-final%20proof3.pdf
Alternate Webpage(s)	http://apjcn.nhri.org.tw/server/APJCN/24/4/683.pdf
Alternate Webpage(s)	http://apjcn.org/update/pdf/0000/0/2014-0190/2014-0190-online.pdf
PubMed reference number	26693754v1
Alternate Webpage(s)	https://doi.org/10.6133/apjcn.2015.24.4.09
DOI	10.6133/apjcn.2015.24.4.09
Journal	Asia Pacific journal of clinical nutrition
Volume Number	24
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	Community Confidence Intervals Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Hypertensive disease Odds Ratio homocysteine
Content Type	Text
Resource Type	Article