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Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chong, Qinglei Xin, Xiaoyi Wang, Chunxiang Wan, Boshun |
| Copyright Year | 2013 |
| Abstract | The Michael addition and three-component cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates to form pyridones has been developed. Aliphatic amines and aromatic amines could selectively be converted into N-alkyl-disubstituted 2-pyridones and N-aryl-trisubstituted 2-pyridones with good yields in the presence of wet ethanol, which means a suitable amount of water is required for this reaction. The Michael addition and cyclization reaction process was confirmed through deuterium-labeling experiments, intermediates isolation and control experiments. |
| Starting Page | 21222 |
| Ending Page | 21226 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C3RA43189D |
| Volume Number | 3 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ra/c3/c3ra43189d/c3ra43189d.pdf |
| Alternate Webpage(s) | http://www.chs.dicp.ac.cn/download/2013-12.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C3RA43189D |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
