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Effects of Divalent Cations on the E-4031-Sensitive Repolarization Current, IKr, in Rabbit Ventricular Myocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Paquette, Tyna Clay, John R. Ogbaghebriel, A. Shrier, Alvin |
| Copyright Year | 1998 |
| Abstract | The effects of divalent cations on the E-4031-sensitive repolarization current (I(Kr)) were studied in single ventricular myocytes isolated from rabbit hearts. One group of divalent cations (Cd2+, Ni2+, Co2+, and Mn2+) produced a rightward shift of the I(Kr) activation curve along the voltage axis, increased the maximum I(Kr) amplitude (i.e., relieved the apparent inward rectification of the channel), and accelerated I(Kr) tail current kinetics. Another group (Ca2+, Mg2+ and Sr2+) had relatively little effect on I(Kr). The only divalent cation that blocked I(Kr) was Zn2+ (0.1-1 mM). Under steady-state conditions, Ba2+ caused a substantial block of I(K1) as previously reported. However, block by Ba2+ was time dependent, which precluded a study of Ba2+ effects on I(Kr). We conclude that the various effects of the divalent cations can be attributed to interactions with distinct sites associated with the rectification and/or inactivation mechanism of the channel. |
| Starting Page | 1278 |
| Ending Page | 1285 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-3495(98)77841-5 |
| Volume Number | 74 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/81927797.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-3495%2898%2977841-5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
