Diastereoselective pictet-spengler reactions towards the synthesis of tetrahydrospiro-pyrido[3,4-b]indoles, tetrahydro pyrrolo[3,2-c]pyridines and octahydrodipyrido[4,3-b;3',4' d]pyrroles

Content Provider	Semantic Scholar
Author	Shumaila, Abdullah Mabkhot Ali
Copyright Year	2010
Abstract	Chapter 1: Introduction Pictet-Spengler reaction has been extensively studied in the area of synthesis of different biologically important heterocyclic systems. Asymmetric Pictet-Spengler reaction has attracted much attention, because it is an important and useful tool to construct chiral synthons containing tetrahydroisoquinoline or tetrahydro-β-carboline (THβC) structural moieties. Therefore, the main challenge of this cyclization is stereoselectivity and the ratio of isomers. Heterocycles form the largest classical divisions of organic chemistry and are of immense importance biologically and industrially. The majority of pharmaceuticals and biologically active chemicals are heterocyclic compounds, which are used in industries as varied as cosmetics, reprography, information storage, and plastics. Heterocyclic compounds like Carbazoles, Tryptamine, Carbolines, Meriadinim G, Variolin B, Porphobilinogen, etc show medicinal properties. In this Chapter we give a brief introduction of PictetSpengler reaction and various heterocycles, their biological activity and natural occurrence.
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