Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Content Provider	Semantic Scholar
Author	Sánchez-Villegas, Almudena Álvarez-Pérez, Jacqueline Toledo, Estefanía Salas-Salvadó, Jordi Ortega-Azorín, Carolina Zomeño, María Dolores Vioque, Jesús Martínez, José Alfredo Romaguera, Dora Pérez-López, Jéssica López-Miranda, Jose Estruch, Ramón Bueno-Cavanillas, Aurora Arós, Fernando Tur, Josep Antoni Tinahones, Francisco J. Lecea, Oscar Martín, Vicente Ortega-Calvo, Manuel Vázquez, Clotilde Pintó, Xavier Vidal, Josep Daimiel, Lidia Delgado-Rodríguez, Miguel Matía, Pilar Corella, Dolores Díaz-López, Andrés Babio, Nancy Muñoz, Miguel Angel Fitó, Montserrat Hera, Manoli García De La Abete, Itziar García-Ríos, Antonio Ros, Emilio Ruíz-Canela, Miguel Martínez-González, Miguel Angel Izquierdo, Marisol Serra-Majem, Lluís
Copyright Year	2018
Abstract	BACKGROUND The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. METHODS Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. RESULTS Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
File Format	PDF HTM / HTML
DOI	10.3390/nu10122000
PubMed reference number	30567286
Journal	Medline
Volume Number	10
Alternate Webpage(s)	https://res.mdpi.com/nutrients/nutrients-10-02000/article_deploy/nutrients-10-02000.pdf?attachment=1&filename=
Alternate Webpage(s)	https://doi.org/10.3390/nu10122000
Journal	Nutrients
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article