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Waveform changes of the first-order multifocal electroretinogram in patients with glaucoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hasegawa, Shinji Takagi, Mineo Usui, Tomoaki Takada, Ritsuko Abe, Haruki |
| Copyright Year | 2000 |
| Abstract | PURPOSE To investigate the relationship between the components of the first-order multifocal electroretinogram (M-ERG) and glaucomatous visual field loss. METHODS Twenty-six eyes of 14 patients with primary open-angle glaucoma (POAG) were evaluated with the M-ERG techniques. Twenty-six eyes of 26 normal subjects also were tested as control subjects. To record the M-ERG, a stimulus matrix of 103 scaled hexagonal elements was displayed on a monitor driven at a 75-Hz frame rate according to a binary m-sequence. The M-ERG responses were averaged in each quadrant of the stimulus field and the peak-to-trough amplitudes and peak implicit times of the first trough (N1), the first peak (P1), and the second trough (N2) of the M-ERG were compared with the mean sensitivity values (dB) of the corresponding quadrant of the Humphrey static perimetric field. RESULTS The changes in the peak latencies of P1 and N2 in the POAG group were small but significant compared with those in the normal group (P < 0.01). However, no significant differences in the amplitudes of (P1-N1) and (P1-N2) between the two groups were found. Significant negative correlations between the peak implicit times of N1, P1, and N2 and the mean sensitivity values (dB) of static perimetry were observed. The correlation coefficients were -0.20 (P < 0.05) for the N1, -0.41 (P < 0.001) for the P1, and -0.59 (P < 0.001) for the N2. No significant correlations were observed between the amplitudes (P1-N1 and P1-N2) and the mean sensitivity values. CONCLUSIONS The present study findings suggest that the peak implicit times, but not the amplitudes, of the M-ERG increase as the glaucomatous visual field deteriorates. The amplitudes of the M-ERG did not decrease as the glaucomatous optic nerve dysfunction progressed. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 10798681 |
| Journal | Medline |
| Volume Number | 41 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://iovs.arvojournals.org/pdfaccess.ashx?url=/data/journals/iovs/932905/7g050001597.pdf |
| Journal | Investigative ophthalmology & visual science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
