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Capecitabine and Vinorelbine in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ahn, Jin-Hee Kim, Sung Bae Kim, Taewon Ahn, Sei Hyun Kim, Sun-Mi Park, Jeong-Mi Lee, Jung-Shin Kang, Y. K. |
| Copyright Year | 2004 |
| Abstract | We have evaluated the efficacy and safety of the combination of capecitabine and vinorelbine in metastatic breast cancer (MBC) patients previously treated with anthracycline-and taxane-containing regimens. Between April 2000 and September 2002, 44 female MBC patients received oral capecitabine (1,250 mg/m2 twice daily on days 114), and intravenous vinorelbine (25 mg/m2 on days 1 and 8) during each 3 week-chemotherapy cycle (median, 5 cycles/patient; total, 235 cycles). One patient achieved a complete response and 21 patients had partial responses, giving an overall response rate of 50% in the intention-to-treat analysis (95% CI, 35.0-65.0%). Median duration of response was 6.0 months (range 1.2-23.0 months). Patients were followed- up for a median of 16 months, with median progression-free survival being 5.3 months, and median overall survival being 17 months. Toxicities included grades III and IV neutropenia in 63 (26.8%) and 4 (1.7%) cycles, respectively, and grades II and III hand-foot syndrome in 12 (5.1%) and 4 (1.7%) cycles, respectively. Other nonhematologic toxicities were minimal and manageable. In conclusion, the combination of capecitabine and vinorelbine was effective and well tolerated in MBC patients even after treatment with anthracyclines and taxanes. |
| Starting Page | 547 |
| Ending Page | 553 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 15308846 |
| Volume Number | 19 |
| Journal | Journal of Korean medical science |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b5/5c/jkms-19-547.PMC2816889.pdf |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/b5/5c/jkms-19-547.PMC2816889.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Anthracyclines Carcinoma breast stage IV Grade Mammary Neoplasms Milligram per Square Meter Neutropenia Overall Survival Palmar-plantar erythrodysesthesia syndrome Patients Progression-Free Survival Taxanes capecitabine mecarzole vinorelbine |
| Content Type | Text |
| Resource Type | Article |
