NDLI: Multiple myeloma associated with IgA lambda gammopathy and multiple myeloma oncogene 1 in a Yorkshire terrier

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Multiple myeloma associated with IgA lambda gammopathy and multiple myeloma oncogene 1 in a Yorkshire terrier

Content Provider	Semantic Scholar
Author	Kim, Sangyoung Son, Eunju Lee, Sang-Rae Kim, Hyeong-Cheol Kang, Mingu Lee, Changwook Park, Hongsun
Copyright Year	2018
Abstract	An eight-year-old spayed female Yorkshire terrier was presented with a one-month history of conspicuous weight-bearing lameness in the right hindlimb, mild anorexia, intermittent vomiting and marked polydipsia and polyuria. Radiographs revealed circular radiolucent foci of variable size in the skeleton. Haematological and serum biochemistry examination revealed mild leucopoenia with severe neutropaenia, mild non-regenerative anaemia, moderate thrombocytopoenia, moderate hyperglobulinaemia, mild hypoalbuminaemia, mild azotaemia and moderate hypercalcaemia. Quantification of serum immunoglobulins revealed elevated IgA and IgG. Serum protein electrophoresis showed a broad appearance with a β-region spike. Plasma cells accounted for 7.6% of the cells in the bone marrow. Serum immunofixation electrophoresis (IFE) revealed IgA lambda gammopathy. Immunohistochemistry in the bone marrow was diffusely positive for multiple myeloma oncogene 1 (MUM-1) and CD20. To our knowledge, this is first case report of multiple myeloma associated with IgA lambda gammopathy confirmed via IFE and immunohistochemical expression of MUM-1 in a dog.
Starting Page	187
Ending Page	192
Page Count	6
File Format	PDF HTM / HTML
DOI	10.17221/152/2017-vetmed
Volume Number	63
Alternate Webpage(s)	http://vri.cz/docs/vetmed/63-4-187.pdf
Alternate Webpage(s)	https://doi.org/10.17221/152%2F2017-vetmed
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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