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Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on d[3H]aspartate release from cultured cerebellar granule cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Doble, Adam Hubert, J. Blanchard, J. |
| Copyright Year | 1992 |
| Abstract | The release of D-[3H]aspartate from cultured cerebellar granule cells evoked by glutamic acid can be inhibited by riluzole and the muscarinic agonist carbachol. The combined application of maximally efficacious concentrations of riluzole and carbachol produces no greater inhibition than that seen with either agent alone, indicating that a common mechanism is involved. The effects of both agents are abolished when the cells have been pretreated with pertussis toxin, which suggests that this mechanism may involve a GTP-binding protein. The effect of pertussis toxin pretreatment is not mimicked by cholera toxin, nor does pertussis toxin pretreatment interfere with the inhibitory effect of the competitive excitatory amino acid receptor antagonist D-alpha-aminoadipic acid. |
| Starting Page | 251 |
| Ending Page | 254 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(92)90114-M |
| PubMed reference number | 1354343 |
| Journal | Medline |
| Volume Number | 140 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409290114M |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409290114M?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2892%2990114-M |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
