NDLI: Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy

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Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy

Content Provider	Semantic Scholar
Author	Zhu, Wan-Qi Chen, Guanxuan Zhao, Han-Xi Sun, Xiaorong Meng, Xiangjiao Zhao, Xianguang Xing, Li-Gang Yu, Jinming Zheng, Meizhu
Copyright Year	2016
Abstract	There are few effective treatment options for radiation-induced dermatitis in breast cancer patients. We conducted a single-arm trial to tested the hypothesis that topical epigallocatechin-3-gallate (EGCG) is effective against radiation-induced dermatitis in breast cancer patients undergoing radiotherapy. Forty-nine patients participated in this study. The patients underwent mastectomy followed by adjuvant radiotherapy. Topical EGCG was applied daily, starting when grade I dermatitis appeared and ending two weeks after radiotherapy. The maximum dermatitis observed during the EGCG treatment was as follows: Grade 1 toxicity, 71.4% (35 patients); grade 2 toxicity, 28.6% (14 patients); there were no patients with grade 3 or 4 toxicity. The majority of the radiation-induced dermatitis was observed 1 week after the end of radiotherapy. EGCG reduced the pain in 85.7% of patients, burning-feeling in 89.8%, itching in 87.8%, pulling in 71.4%, and tenderness in 79.6%. These findings suggest topical EGCG may be an effective treatment for radiation-induced dermatitis and has acceptable toxicity.
Starting Page	48607
Ending Page	48613
Page Count	7
File Format	PDF HTM / HTML
DOI	10.18632/oncotarget.9495
PubMed reference number	27224910
Journal	Medline
Volume Number	7
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=9495&path%5B%5D=29595
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.9495
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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