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Amprenavir inhibitory quotient and virological response in human immunodeficiency virus-infected patients on an amprenavir-containing salvage regimen without or with ritonavir.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Duval, Xavier Lamotte, Claire Race, Ester Descamps, Diane Damond, Florence Clavel, François Leport, Catherine Peytavin, Gilles Vildé, Jean-Louis |
| Copyright Year | 2002 |
| Abstract | The efficacy of an amprenavir (APV)-containing therapy without (group A) or with (group B) ritonavir was assessed in patients with failure of previous protease inhibitor therapy for human immunodeficiency virus (HIV) infection. The mean minimal plasma APV concentrations in groups A and B were 58 and 1,320 ng/ml, respectively, corresponding to APV inhibitory quotients of 0.2 (range, 0.03 to 0.70) and 7.0 (range, 1.4 to 145), respectively. At week 24, 2 of 8 and 13 of 14 patients in groups A and B, respectively, had <200 HIV RNA copies/ml of plasma, including 4 of 5 patients infected with APV-resistant viruses. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/AAC.46.2.570-574.2002 |
| PubMed reference number | 11796381 |
| Journal | Medline |
| Volume Number | 46 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://aac.asm.org/content/46/2/570.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/AAC.46.2.570-574.2002 |
| Journal | Antimicrobial agents and chemotherapy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
