NDLI: Phytochemical screening, antimicrobial and antioxidant properties of assorted Carica papaya leaves in Ghana

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Phytochemical screening, antimicrobial and antioxidant properties of assorted Carica papaya leaves in Ghana

Content Provider	Semantic Scholar
Author	Alorkpa, Esther Boadi, Nathaniel Owusu Badu, Mercy Saah, Selina A.
Copyright Year	2016
Abstract	The bioactive compounds of the leaves of Carica papaya; solo and solomix were extracted using ethanol and n-hexane, and investigated for the presence of secondary metabolites. Both ethanol and n-hexane extracts revealed the presence of alkaloids. Flavonoids, glycosides and saponins were present in only the ethanol extract whereas tannins were present in the n-hexane extract. The bioactivities of the leaf extracts were attributed to their phytochemical constituents. Antimicrobial activity of the extracts were determined against some human pathogenic bacteria and fungi such as Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Bacillus subtilis and Candida albicans using the agar well diffusion and broth dilution methods with the polar extract being more effective. The ethanol extract demonstrated a significant broad-spectrum antimicrobial activity against both gram-positive and gramnegative bacteria, with the highest activity having a zone of inhibition of 10 mm. Antioxidant activity was determined using the DPPH assay method and the absorbance measured using UVvisible spectrophotometer with ascorbic acid as control. The antioxidant activities of solo and solomix showed IC50 of 1.465x10-2 and 1.364x 10-2 respectively. This study demonstrates the efficacy of ethanolic leaf extracts of C. Papaya as an alternative antibiotic for the development of newer antibacterial agents.
Starting Page	193
Ending Page	198
Page Count	6
File Format	PDF HTM / HTML
Volume Number	4
Alternate Webpage(s)	http://www.plantsjournal.com/archives/2016/vol4issue6/PartC/4-6-6-858.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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