NDLI: Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli

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Exposure of rat spinal neurones to NMDA, AMPA and kainate produces only short-term enhancements of responses to noxious and non-noxious stimuli

Content Provider	Semantic Scholar
Author	Cumberbatch, Michael J. Herrero, Juan F. Headley, Philip M.
Copyright Year	1994
Abstract	The ability of excitatory amino acids (EAAs) to modulate nociceptive and non-nociceptive responses was tested on spinal neurones of the anaesthetized rat. NMDA (N-methyl-D-aspartate), AMPA ((RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate) and kainate were applied by iontophoretic ejection to increase the background firing rate of each cell to approximately 25 spikes/s. Responses to noxious heat and pinch and innocuous tap stimuli were enhanced to similar degrees by all three EAAs and returned to control immediately following termination of EAA ejection. This result shows that, whilst NMDA does enhance synaptic responses of spinal neurones, this effect is little or no greater than for AMPA or kainate. Furthermore, the rapid recovery of nociceptive responses indicates that more than NMDA receptor activation alone is required to induce longer-term enhancement of nociceptive responses (hyperalgesia).
Starting Page	98
Ending Page	102
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(94)90569-X
PubMed reference number	7534894
Journal	Medline
Volume Number	181
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409490569X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409490569X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2894%2990569-X
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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