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Piperacillin/tazobactam vs. cefoperazone/sulbactam in adult low-risk febrile neutropenia cases.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sipahi, Oğuz Reşat Arda, Bilgin Zeka, Arzu Nazli‐ Pullukçu, Hüsnü Taşbakan, Meltem Yamazhan, Tansu Ozkoren-Calik, S. Sipahi, Hande Ulusoy, Sercan |
| Copyright Year | 2014 |
| Abstract | AIM The aim of this study was to compare the efficacy of piperacillin/tazobactam (P/T) and cefoperazone/sulbactam (C/S) in the empirical treatment of adult neutropenic fever. METHODS Data and outcomes of low-risk adult cases with neutropenic fever and treated with P/T (4.5 g q6h) or C/S (2 g q8h) between 2005 and 2011 June were extracted from our database. Risk evaluation was made according to criteria of Multinational Association for Supportive Care in Cancer (MASCC) and a score of ≥ 21 was considered as low risk. Data were collected prospectively by daily visits and evaluated retrospectively. Primary outcome was - fever defervescence at 72 h in combination with success without modification (referring to episodes where the patient recovered from fever with disappearance of signs of infection without modification to initial empirical treatment). All-cause mortality referred to death resulting from a documented or presumed infection or unidentified reason during the treatment and 30-day follow-up period. RESULTS A total of 172 patients (113 cases P/T and 59 cases C/S) fulfilled the study inclusion criteria. Persistent response in P/T arm was 73.5%, whereas it was 64.5% in C/S arm (p > 0.05). Rates of any modification were also similar in both treatment arms. All-cause mortality during the treatment and 30-day follow-up period was not significantly different (P/T: 4/113 vs. C/S: 2/59, p > 0.05). There was no severe adverse effect requiring antibiotic cessation in both cohorts. CONCLUSION In conclusion, our data suggest that C/S may be a safe alternative to P/T in the empirical treatment of adult low-risk febrile neutropenia cases. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/ijcp.12279 |
| Alternate Webpage(s) | http://sipahi.tk/y52.pdf |
| PubMed reference number | 24372736 |
| Alternate Webpage(s) | https://doi.org/10.1111/ijcp.12279 |
| Journal | Medline |
| Volume Number | 68 |
| Issue Number | 2 |
| Journal | International journal of clinical practice |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
