Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects.

Content Provider	Semantic Scholar
Author	Elias, Lucila L. K. Antunes-Rodrigues, José Moreira, Ayrton Custódio
Copyright Year	1997
Abstract	The existence of a circadian rhythm of atrial natriuretic peptide (ANP) in humans is controversial. We studied the plasma ANP response to isotonic blood volume expansion in the morning and in the afternoon and its relationship with adrenocorticotropic hormone (ACTH)-cortisol diurnal variation in seven normal subjects. Basal plasma ANP level was similar in the morning (19.6 +/- 2.4 pg/ml) and in the afternoon (21.8 +/- 4.8 pg/ml). The ANP peak obtained with saline infusion (0.9% NaCl, 12 ml/kg) in the morning (49.4 +/- 8 pg/ml) did not differ from that obtained in the afternoon (60.3 +/- 10.1 pg/ml). There was no correlation between the individual mean cortisol and ACTH levels and the ANP peak obtained with saline infusion. These data indicate no diurnal variation in plasma ANP secretion induced by blood volume expansion and no relationship between plasma ANP peak and ACTH-cortisol diurnal variation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/bjmbr/v30n5/2500C.pdf
PubMed reference number	9283629v1
Volume Number	30
Issue Number	5
Journal	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Language	English
Access Restriction	Open
Subject Keyword	Atrial Natriuretic Factor Axis vertebra Circadian Rhythms Corticotropin Epinephrine Heart Atrium Hydrocortisone Nanogram per Liter Sodium Chloride
Content Type	Text
Resource Type	Article