A chiral samarium-based catalyst for the asymmetric Meerwein-Ponndorf-Verley reduction

Content Provider	Semantic Scholar
Author	Evans, David A. D. Nelson, Scott G. Gagné, Michel R. Muci, Alexander R.
Copyright Year	1993
Abstract	The Meerwein-Ponndorf-Verley (MPV) reduction enjoys a prominent historical position in synthesis methodology,' and milder variants of this process utilizing trivalent lanthanide catalysts continue to improve the utility of this reaction for the reduction of ketones.2 The purpose of this communication is to report an enantioselective variant of the MPV reduction which is catalyzed by a chiral samarium(II1) complex at ambient temperatures in 2-propan01.~ On the basis of precedent established by Kagan,2 a range of Sm(II1) complexes were generated from freshly prepared Sm13 and chiral biand tridentate ligands. These complexes were screened as catalysts in the reduction of o-chloroacetophenone (25 equiv of 2-propanol, 25 "C) (eq 1). This screening process
Starting Page	9800
Ending Page	9801
Page Count	2
File Format	PDF HTM / HTML
DOI	10.1021/ja00074a057
Volume Number	115
Alternate Webpage(s)	http://evans.rc.fas.harvard.edu/pdf/evans176.pdf
Alternate Webpage(s)	https://doi.org/10.1021/ja00074a057
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article