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Polymer biophotonic lab-ona-chip with integrated organic semiconductor lasers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vannahme, Christoph Klinkhammer, Soenke Lemmer, Uli |
| Copyright Year | 2009 |
| Abstract | Lab-on-a-chip devices (LOCs) enable biomedical or chemical tests for point-of-care analysis or screening.1 Optical sensing promises high sensitivity and the possibility of detection without chemical markers. This will speed up response time and reduce the need for chemicals by skipping the labeling steps commonly used in marker-based approaches. We are developing optofluidic LOCs for single use as disposable tests. Most current disposable sensor chips are based on a combination of different materials, such as glasses, polydimethylsiloxane, silicon, and polymers. All-organic LOCs offer the advantages of biocompatibility, fabrication flexibility, and low raw-material cost.2 Our approach aims to create systems from poly(methyl methacrylate) (PMMA) that integrate organic lasers,3 optical waveguides,4 microfluidic channels, surface functionalization, and fluorescence excitation on a single chip. We are using mass-production techniques5 to show the applicability of this approach, by avoiding electrical interconnects and instead relying on optical and fluidic interfaces. We demonstrated feasibility by combining two consecutive elements of the light path. First, we added organic semiconductor lasers by imprinting a distributed-feedback (DFB) grating into PMMA. We then evaporated a thin film of photoactive material on top of this structure. The lasing wavelength is within the visible-light regime and widely tunable within the gain spectrum of the organic active material.6 We coupled the emitted light from the DFB laser into polymer-strip optical waveguides, which direct light to a microfluidic channel.7 Tailored surface functionalization in the channel enables local Figure 1. Sketch of an uncovered, disposable lab-on-a-chip device with integrated organic lasers, deep-UV (DUV)-induced waveguides, and a microfluidic channel. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.spie.org/documents/Newsroom/Imported/1788/1788_6200_0_2009-09-08.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
