NDLI: Protection against bacteremic pneumococcal infection by antibody to pneumolysin.

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Protection against bacteremic pneumococcal infection by antibody to pneumolysin.

Content Provider	Semantic Scholar
Author	Phan, Huy Minh
Copyright Year	2001
Abstract	Pneumolysin is an important virulence factor of Streptococcus pneumoniae. This study examined the hypothesis that human antibody to pneumolysin provides protection against pneumococcal infection. At the time of hospital admission, patients with nonbacteremic pneumococcal pneumonia had higher levels of serum anti-pneumolysin IgG than did patients with bacteremic pneumococcal pneumonia or uninfected control subjects. IgG levels rose significantly during convalescence in patients with bacteremic pneumonia, reaching levels observed in nonbacteremic patients. Purified human anti-pneumolysin IgG protected mice against intraperitoneal challenge with S. pneumoniae types 1 or 4 in a dose-related fashion; mice that received anti-pneumolysin IgG had a greater likelihood of surviving challenge and had negative blood cultures. Pneumolysin damages epithelial cells and inhibits phagocytic function of polymorphonuclear leukocytes. One hypothesis that might explain the study results is that, early in infection, IgG to pneumolysin blocks these effects in the alveoli, thereby protecting the host against bacteremic pneumococcal disease.
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PubMed reference number	11181163v1
Volume Number	183
Issue Number	5
Journal	The Journal of infectious diseases
Language	English
Access Restriction	Open
Subject Keyword	Alveolus Blood culture Paget's Disease, Mammary Patients Pneumococcal Infections Pneumocystis jiroveci pneumonia Polyvalent pneumococcal vaccine Streptococcal pneumonia Virulence Factors neutrophil plY protein, Streptococcus pneumoniae
Content Type	Text
Resource Type	Article

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