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Familial risks for cervical tumors in full and half siblings: etiologic apportioning.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hemminki, Kari Chen, Bowang |
| Copyright Year | 2006 |
| Abstract | Many studies have shown familial aggregation for cervical cancer, but they have been unable to distinguish between shared environmental and genetic effects. Full and half-siblings were identified from the nationwide Swedish Family-Cancer Database, including invasive and in situ cervical cancers in women up to age 70 years. Half-siblings were defined through a common father or mother. Standardized incidence ratios, adjusted for several variables, were calculated for proband-wise risks between full and half-siblings. The familial risk for full siblings was 1.84, compared with 1.40 for maternal and 1.27 for paternal half-siblings. These data were used to apportion familial risk for cervical tumors in full siblings into a heritable component, accounting for 64%, and an environmental component, accounting for 36% of the total risk. No evidence for gene-environment interactions was found. The intractable difficulty in separating cervical cancer causation will be an obstacle for a successful identification of susceptibility genes. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://cebp.aacrjournals.org/content/cebp/15/7/1413.full.pdf |
| PubMed reference number | 16835346v1 |
| Volume Number | 15 |
| Issue Number | 7 |
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenomatous Polyposis Coli Cervix carcinoma Neck Neoplasms Uterine Cervical Neoplasm cervical cancer |
| Content Type | Text |
| Resource Type | Article |
