NDLI: Localisation of a gene causing endocrine neoplasia to a 4 cM region on chromosome 1p35-p36.

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Localisation of a gene causing endocrine neoplasia to a 4 cM region on chromosome 1p35-p36.

Content Provider	Semantic Scholar
Author	Williamson, Christine Wooding, Carol McCarthy, Mary Ann Sheppard, Mary Noelle Thakker, Rajesh V.
Copyright Year	1997
Abstract	The development of some endocrine tumours, such as medullary thyroid carcinomas, phaeochromocytomas, anterior pituitary adenomas, and parathyroid adenomas involve a putative tumour suppressor gene located on chromosome 1p32-pter, a region that represents 111 cM. In order to refine the location of this gene, 93 endocrine tumours (39 parathyroid adenomas, 40 anterior pituitary adenomas, seven pancreatic islet cell adenomas, and seven carcinoids) were investigated for loss of tumour heterozygosity (LOH) using the seven polymorphic loci 1pter-D1S228-D1S507-D1S234-D1S476-D1S22 0-D1S207-D1S206-1cen. LOH was detected in 27% of the parathyroid tumours and in 7.5% of the pituitary tumours, but in none of the pancreatic islet cell or carcinoid tumours. In addition, seven of the 10 parathyroid tumours that showed LOH of chromosome 1p facilitated a more precise mapping of this putative tumour suppressor gene; five tumours involved a loss only of the telomeric locus D1S228, whereas two other tumours showed LOH at the centromeric loci D1S507, D1S234, D1S476, and D1S220, but not D1S228. Thus, our results have mapped this tumour suppressor gene implicated in endocrine tumours to a 4 cM region flanked by D1S228 and D1S507 on chromosome 1p35-p36.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jmg.bmj.com/content/jmedgenet/34/8/617.full.pdf
PubMed reference number	9279750v1
Volume Number	34
Issue Number	8
Journal	Journal of medical genetics
Language	English
Access Restriction	Open
Subject Keyword	Adrenal Medulla Carcinoid Tumor Chromosome 1 Short Arm Endocrine Gland Neoplasms Endocrine System Diseases Genes, vif Heterozygote Islet Cell Adenoma Islets of Langerhans Loss of Heterozygosity Medullary carcinoma of thyroid Parathyroid Adenoma Parathyroid Neoplasms Pituitary Adenoma Pituitary Hormones, Anterior Pituitary Neoplasms Thyroid Diseases
Content Type	Text
Resource Type	Article

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