NDLI: Synthesis, characterization, and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites

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Synthesis, characterization, and efficacy of antituberculosis isoniazid zinc aluminum-layered double hydroxide based nanocomposites

Content Provider	Semantic Scholar
Author	Saifullah, Bullo Zowalaty, Mohamed E. El Arulselvan, Palanisamy Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin Mahler Hussein, Mohd Zobir
Copyright Year	2016
Abstract	The chemotherapy for tuberculosis (TB) is complicated by its long-term treatment, its frequent drug dosing, and the adverse effects of anti-TB drugs. In this study, we have developed two nanocomposites (A and B) by intercalating the anti-TB drug isoniazid (INH) into Zn/Al-layered double hydroxides. The average size of the nanocomposites was found to bê164 nm. The efficacy of the Zn/Al-layered double hydroxides intercalated INH against Mycobacterium tuberculosis was increased by approximately three times more than free INH. The nanocomposites were also found to be active against Gram-positive and -negative bacteria. Compared to the free INH, the nanodelivery formulation was determined to be three times more biocompatible with human normal lung fibroblast MRC-5 cells and 3T3 fibroblast cells at a very high concentration of 50 µg/mL for up to 72 hours. The in vitro release of INH from the Zn/Al-layered double hydroxides was found to be sustained in human body-simulated buffer solutions of pH 4.8 and 7.4. This research is a step forward in making the TB chemotherapy patient friendly.
Starting Page	3225
Ending Page	3237
Page Count	13
File Format	PDF HTM / HTML
DOI	10.2147/IJN.S102406
PubMed reference number	27486322
Journal	Medline
Volume Number	11
Alternate Webpage(s)	https://www.dovepress.com/getfile.php?fileID=31393
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/cf/ijn-11-3225.PMC4956062.pdf
Alternate Webpage(s)	https://doi.org/10.2147/IJN.S102406
Journal	International journal of nanomedicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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