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Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Poursalehi, Hamid Reza Fekri, Mitra Samareh Far, F. Sharifi Mandegari, Ali Izadi, Atefe Mahmoodi, Rahil Nematollahi, Hadi Porgholamhosein, Fateme Ghorani, Vahideh Fekri, Masome Samareh |
| Copyright Year | 2018 |
| Abstract | Objective Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods This study was carried out using 52 rats. Pulmonary fibrosis was induced by a single endotracheal injection of bleomycin (5 mg/kg). Extract of N. sativa (500 mg/kg per day) or methylprednisolone succinate (4 mg/kg per day) was injected intraperitoneally in two periods (i.e. days 1-14 as early preventive group and days 15-28 days as late preventive group). The lung tissues were histologically examined at the end of each period and inspected for the amount of hydroxyproline and biomarkers of oxidative stress. Results The pulmonary inflammation and fibrosis were significantly decreased in groups treated with methylprednisolone and N. sativa extract compared to bleomycin group in both early and late prevention groups (p<0.001). The hydroxyproline concentration in pulmonary tissue was significantly decreased in N. sativa and methylprednisolone groups compared to the bleomycin group in both prevention groups (p<0.001). Significant reductions in lipid peroxidation (p<0.001) and increases in catalase activity were also observed in N. sativa and methylprednisolone groups compared to bleomycin group. Conclusion This study suggested that N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation. However, more studies are needed to identify its anti-inflammatory and anti-fibrotic mechanisms in the respiratory system. |
| Starting Page | 263 |
| Ending Page | 275 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajp.mums.ac.ir/article_10265_d1cfa786d65199120d2d71a04b991527.pdf |
| PubMed reference number | 5987441 |
| Volume Number | 8 |
| Journal | Avicenna journal of phytomedicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anti-Inflammatory Agents Bleomycin CATALASE Connective Tissue Hydroxyproline Inflammation Lipid Peroxidation Lung diseases Methylprednisolone Hemisuccinate Nigella (plant) Nigella sativa Oxidative Stress Pneumonia Pulmonary Fibrosis Pulmonary Subvalvular Stenosis Structure of parenchyma of lung Succinates mg/kg |
| Content Type | Text |
| Resource Type | Article |
