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Clinical and biochemical markers of visceral adipose tissue activity: Body mass index, visceral adiposity index, leptin, adiponectin, and matrix metalloproteinase-3. Correlation with Gleason patterns 4 and 5 at prostate biopsy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Siracusano, Salvatore Abrate, Alberto Gesolfo, Cristina Scalici Vella, Marco Maida, Fabrizio Di Cangemi, Antonina Dorangricchia, Patrizia Barresi, Elisabetta Sanfilippo, Chiara |
| Copyright Year | 2018 |
| Abstract | Context The correlation between aggressive prostate cancer and obesity mainly based on body mass index (BMI) and pathology after surgery remains controversial. Aims The aim of the study was to correlate BMI, visceral adiposity index (VAI), and the plasmatic levels of leptin, adiponectin, and matrix metalloproteinase-3 (MMP-3), and biomarkers of adipose tissue function, with the detection of Gleason patterns 4 and 5 at biopsy. Subjects and Methods Consecutive patients with prostate cancer at 12-core transrectal biopsy were enrolled. BMI, waist circumference (WC), blood samples to evaluate the plasmatic levels of triglycerides (TG) and high-density lipoproteins (HDL), adiponectin, leptin, and MMP-3 were obtained immediately before biopsy. The VAI was calculated according to the formula: WC/(39.68 + [1.88 × BMI]) × TG/1.03 × 1.31/HDL. Results One hundred and forty-nine patients were entered. The median PSA, BMI, and VAI were 10.0 ng/ml, 27.6 kg/m2, and 4.6, respectively. Gleason patterns 4 or 5 were detected in 68 (45.6%) patients; in 15 (41.7%), 31 (44.9%), and 22 (50.0%) among normal weight, overweight, and obese patients, respectively (P = 0.55). The statistical analysis did not show any significant correlation between BMI, VAI, the plasmatic levels of leptin, adiponectin, MMP-3, and the detection of Gleason patterns 4 and 5 at biopsy. A statistically significant association emerged with older age (P = 0.017) and higher PSA values (P = 0.02). Conclusion We did not find any association between BMI, VAI, the plasmatic levels of adiponectin, leptin, and MMP-3 and the detection of Gleason patterns 4 and 5 at prostate biopsy. |
| Starting Page | 280 |
| Ending Page | 286 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30089986v1 |
| Alternate Webpage(s) | https://doi.org/10.4103/UA.UA_188_17 |
| DOI | 10.4103/ua.ua_188_17 |
| Journal | Urology annals |
| Volume Number | 10 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adiponectin Adipose tissue Biological Markers Biopsy of prostate Blood specimen Body Dysmorphic Disorders Body mass index Forty Nine High Density Lipoproteins Kilogram Per Square Meter Leptin measurement MMP3 protein, human Obesity Overweight Patients Prostatic Neoplasms Transrectal Biopsy Triglycerides Waist Circumference |
| Content Type | Text |
| Resource Type | Article |
