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Treatment of unipolar psychotic depression: a randomized, double-blind study comparing imipramine, venlafaxine, and venlafaxine plus quetiapine.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wijkstra, Jaap Burger, Helena Broek, Walter W. Van Den Birkenhäger, Tom K. Janzing, Joost G. E. Boks, Marco Paul Maria Bruijn, Jan A. Loos, Marc L. M. Van Der Breteler, Leonie M. T. Ramaekers, Guilaume M. G. I. Verkes, Robbert Jan Nolen, Willem A. |
| Copyright Year | 2010 |
| Abstract | OBJECTIVE It remains unclear whether unipolar psychotic depression should be treated with an antidepressant and an antipsychotic or with an antidepressant alone. METHOD In a multi-center RCT, 122 patients (18-65 years) with DSM-IV-TR psychotic major depression and HAM-D-17 > or = 18 were randomized to 7 weeks imipramine (plasma-levels 200-300 microg/l), venlafaxine (375 mg/day) or venlafaxine-quetiapine (375 mg/day, 600 mg/day). Primary outcome was response on HAM-D-17. Secondary outcomes were response on CGI and remission (HAM-D-17). RESULTS Venlafaxine-quetiapine was more effective than venlafaxine with no significant differences between venlafaxine-quetiapine and imipramine, or between imipramine and venlafaxine. Secondary outcomes followed the same pattern. CONCLUSION That unipolar psychotic depression should be treated with a combination of an antidepressant and an antipsychotic and not with an antidepressant alone, can be considered evidence based with regard to venlafaxine-quetiapine vs. venlafaxine monotherapy. Whether this is also the case for imipramine monotherapy is likely, but cannot be concluded from the data. |
| Starting Page | 190 |
| Ending Page | 200 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1600-0447.2009.01464.x |
| PubMed reference number | 19694628 |
| Journal | Medline |
| Volume Number | 121 |
| Issue Number | 3 |
| Alternate Webpage(s) | https://www.rug.nl/research/portal/files/14639300/05c5.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1600-0447.2009.01464.x |
| Journal | Acta psychiatrica Scandinavica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
