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ERCC 2 ( Excision repair cross-complementing rodent repair deficiency , complementation group 2 )
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stary, Anne Sarasin, Alain |
| Copyright Year | 2011 |
| Abstract | 5'-3' ATP-dependent helicase activity involved in D NA excision repair (NER) and as a subunit of the basal transcription factor TFIIH. The XPD gene product displayed 5'-3' helicase activ ity. The XPD as the XPB protein are also found in the transcription factor TFIIH, a large complex involve d in the initiation of transcription The striking discov ery that subunits of basal transcription factor TFIIH w ere involved in Nucleotide Excision Repair (NER) sheds light on a new aspect of NER : a close coupling to transcription via common use of essential factors. TFIIH fulfills a dual role in transcription initiat ion and NER and the role of TFIIH in NER might closely mimic its role in the transcription initiation proc ess. In transcription initiation TFIIH is thought to be inv ol ed in unwinding of the promoter site and to allow promoter clearance. In the NER process TFIIH causes unwinding of the damage containing region that has been localized by XPC-HR23B and XPA-RPA, enabling the accumulation of NER proteins around th e damaged site. Contrarely to the XPB helicase, the helicase activity of XPD is indispensable for NER b ut not for transcription initiation. So, there is much more XPD patients, and only two patients have been described as XP and CS. |
| File Format | PDF HTM / HTML |
| DOI | 10.4267/2042/37725 |
| Alternate Webpage(s) | http://documents.irevues.inist.fr/bitstream/handle/2042/37725/02-2001-XPDID297.pdf;jsessionid=598017BF1744E59269B6BE379906EA54?sequence=3 |
| Alternate Webpage(s) | https://doi.org/10.4267/2042%2F37725 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
