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Neutral endopeptidase modulation of septic shock
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gerard, Norma P. Kolakowski, Lee F. Bozza, Marcelo Zurakowski, David Finco, Oretta Carroll, Michael C. Gerard, Craig |
| Copyright Year | 1995 |
| Abstract | Neutral endopeptidase (NEP; EC. 3.4.24.11) is a type 2 cell surface metalloprotease known by a variety of eponyms, including enkephalinase, common acute lymphoblastic leukemia antigen, and CD10. Identified substrates are largely neural or humoral oligopeptide agonists, and the enzyme functions to terminate signaling by degrading the ligand, analogously to acetylcholine/acetylcholinesterase. Targeted disruption of the NEP locus in mice results in enhanced lethality to endotoxin shock with a pronounced gene dosage effect. The site(s) of action appears downstream from release of tumor necrosis factor and interleukin-1 since NEP-deficient animals demonstrate increased sensitivity to these mediators as well. This unexpected finding indicates an important protective role for NEP in septic shock. |
| Starting Page | 2271 |
| Ending Page | 2275 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jem.rupress.org/content/jem/181/6/2271.full.pdf |
| PubMed reference number | 7760013v1 |
| Volume Number | 181 |
| Journal | The Journal of experimental medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Endopeptidases Eponyms Heat-Shock Proteins 70 Leukemia, Myelocytic, Acute Metalloproteases Neprilysin Oligopeptides Precursor Cell Lymphoblastic Leukemia Lymphoma Septic Shock lymphoblast tumor necrosis |
| Content Type | Text |
| Resource Type | Article |
