NDLI: Volume-weighted mean glomerular volume in spontaneously hypertensive rats treated with different doses of spironolactone.

Please wait, while we are loading the content...

Volume-weighted mean glomerular volume in spontaneously hypertensive rats treated with different doses of spironolactone.

Content Provider	Semantic Scholar
Author	Pereira, Leila Maria Meirelles Querido, Danielle L. Madeira, A. C. Mandarim-De-Lacerda, Carlos Alberto
Copyright Year	2002
Abstract	OBJECTIVES Ascertain alterations in volume-weighted glomerular volume in monotherapy of spontaneously hypertensive rats with different doses of spironolactone. MATERIAL AND METHODS We have studied young adult male spontaneously hypertensive rats (SHR) 20 weeks old, divided in 4 groups of 5 animals each: Controls, spironolactone lower dose (5mg/kg/day), spironolactone average dose (10mg/kg/day), and spironolactone higher dose (30mg/kg/day) dissolved in drinking water (for 12 weeks). Serum albumin, blood urea nitrogen (BUN), and creatinine, and the volume-weighted mean glomerular volume (VWGV) were measured. RESULTS Common progress of blood pressure (BP) in young adult SHR was greatly altered by spironolactone treatment, by either attenuation or reversion of BP increasing tendency. Biochemical evaluation of kidney function indicated normal levels for albumin and creatinine, and high levels for BUN in SHR in all groups. Thickened intrarenal arteries and venous stasis were observed in all groups. Treated SHR spironolactone average and higher doses glomeruli presented smaller and more regular profiles; glomerular hypertrophy with glomerular tuft gross disarray in controls and treated SHR spironolactone lower dose was observed. VWGV was significantly greater in control and treated SHR spironolactone lower dose than in treated SHR spironolactone average and higher doses. CONCLUSIONS Monotherapy with spironolactone may affect glomerular size and shape in a dose-dependent way; spironolactone showed a significant effect in preserving VWGV, and may be used associated with other drugs in antihypertensive therapy to prevent secondary effects of hypertension in the kidney.
File Format	PDF HTM / HTML
PubMed reference number	15748344
Journal	Medline
Volume Number	28
Issue Number	4
Alternate Webpage(s)	http://www.brazjurol.com.br/july_august_2002/Pereira_ing_356_362.pdf
Journal	International braz j urol : official journal of the Brazilian Society of Urology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in