NDLI: Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma

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Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma

Content Provider	Semantic Scholar
Author	Song, Ye Zheng, Shihao Wang, Jizhou Long, Hao Fang, Luxiong Wang, Gang S. Li, Zhiyong Que, Tianshi Liu, Yi Li, Yilei Zhang, Xi’an Fang, Weiyi Qi, Songtao
Copyright Year	2017
Abstract	Gliomas are the most common form of malignant primary brain tumors with poor 5-year survival rate. Dysregulation of procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) was observed in gliomas, but the specific role and molecular mechanism of PLOD2 in glioma have not been reported yet. In this study, PLOD2 was found to be frequently up-regulated in glioma and could serve as an independent prognostic marker to identify patients with poor clinical outcome. Knockdown of PLOD2 inhibited proliferation, migration and invasion of glioma cells in vitro and in vivo. Mechanistically, inhibition of PLOD2 inactivated PI3K/AKT signaling pathway and thus regulated the expression of its downstream epithelial-mesenchymal transition (EMT)-associated regulators, including E-cadherin, vimentin, N-cadherin, β-catenin, snail and slug in glioma cells. Moreover, PLOD2 could be induced by hypoxia-inducible factor-1α (HIF-1α) via hypoxia, thereby promoting hypoxia-induced EMT in glioma cells. Our data suggests that PLOD2 may be a potential therapeutic target for patients with glioma.
Starting Page	41947
Ending Page	41962
Page Count	16
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=16710&path%5B%5D=53438
PubMed reference number	28410212v1
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.16710
DOI	10.18632/oncotarget.16710
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Brain Neoplasms Cadherins Carcinoma Glioma HIF1alpha protein Hyperlysinemias Hypoxia Lysine PLOD2 gene Patients Primary malignant neoplasm of brain Procollagen Promotion (action) Proto-Oncogene Proteins c-akt Signal Transduction Pathways alpha-ketoglutarate epithelial to mesenchymal transition negative regulation of Notch signaling pathway involved in somitogenesis
Content Type	Text
Resource Type	Article

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