NDLI: 9 vsP 2000 EPC-K 1 PROTECTS NEURONAL CELLS FROM PEROXYNITRITE-MEDIATED OXIDATIVE DAMAGE

Content Provider	Semantic Scholar
Author	Wei, Taotao Xin, Wenjuan Hou, Jingwu
Copyright Year	2009
Abstract	Protective effects of EPC-Ki (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12trimethyldecyl)-2H-I-benzopyran-6-yl-hydrogen phosphate] potassium salt, a difunctional derivative of vitamin C and vitamin E) on neuronal cell damage mediated by peroxynitrite were studied. Primary cultures of cerebellar granule cells were exposed to peroxynitrite by treatment with 3morpholinosydnonimine-N-ethylcarbamide (SIN-I), which generated nitric oxide and superoxide anion simultaneously upon decomposition. The results showed that SIN-I trealment lriggered time-dependent cell death, which was accompanied by the decrease in the cellular GSH level, the increase in the lipid peroxidation level, and the alteration of cell membrane biophysical characteristics. EPC-KI showed only moderate scavenging effect on peroxynitrite, but could effectively protect neuronal cells from oxidative damage mediated by peroxynitrite.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://library.ibp.ac.cn/html/slwj/000168532500003.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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