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Alterations of Ventilation to Perfusion Ratios Distribution Associated with Successive Clinical Stages of Pulmonary Emphysema.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lenfant, Claude Pace, W. R. |
| Copyright Year | 1965 |
| Abstract | Studies reported by Briscoe and co-workers (1) and Finley (2) have demonstrated the blood gas abnormalities of patients with pulmonary emphysema to be mainly the result of impaired distribution of the ventilation to perfusion (VA/Q) ratios throughout the lung. Finley provided no information about the differences in clinical severity of his subjects, however, and Briscoe and co-workers apparently studied patients representing only one stage of the disease according to the classification of Baldwin, Cournand, and Richards (3). Thus, neither study established the actual nature of changes in VA/Q distribution that develop as the disease progresses. Unanswered is the question of whether there occurs an increase of range,' of dispersion, or of both. Yet it is important to know what modifications develop as the disease worsens, because knowledge of these progressive changes may lead to a better understanding of the basic physiological impairments occurring with age (4, 5). This paper is a report of experiments that were made in an attempt to assess the nature of the differences in VA/Q distribution present in three groups of subjects selected ac- |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/105000/105263/JCI65105263.pdf |
| PubMed reference number | 14332169v1 |
| Volume Number | 44 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Congenital Abnormality Hematological Disease Parkinson Disease Patients Pulmonary Emphysema Respiration Structure of parenchyma of lung |
| Content Type | Text |
| Resource Type | Article |
