NDLI: Topographic patterns of brain functional impairment progression according to clinical severity staging in 116 Alzheimer disease patients: FDG-PET study.

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Topographic patterns of brain functional impairment progression according to clinical severity staging in 116 Alzheimer disease patients: FDG-PET study.

Content Provider	Semantic Scholar
Author	Choo, Il Han Lee, Dong Young Youn, Jong Choul Jhoo, Jin Hyeong Kim, Ki Woong Lee, Dong Soo Lee, Jae Sung Woo, Jong Inn
Copyright Year	2007
Abstract	The study aimed to explore topographic progression pattern of brain functional impairment according to clinical stage in Alzheimer disease (AD). One hundred and sixteen AD patients and 25 normal subjects underwent a [18F] fluorodeoxyglucose-positron emission tomography scan. Regional cerebral glucose metabolism was compared between severity groups based on the Clinical Dementia Rating through voxel-based analyses. As clinical severity progressed, hypometabolic areas gradually increased, involving initially posterior cingulate cortex, later temporoparietal, and finally frontal and some subcortical areas. The results indicate that progression patterns of hypometabolism in AD are close to that of typical neuropathology, but that they do not fully coincide with it.
Starting Page	77
Ending Page	84
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://fmisl.snu.ac.kr/Reprint/International/2007ADAD(AD116,IHChoo).pdf
PubMed reference number	17545731v1
Volume Number	21
Issue Number	2
Journal	Alzheimer disease and associated disorders
Language	English
Access Restriction	Open
Subject Keyword	Alzheimer's Disease Cingulate Cortex Cognition Disorders Fluorodeoxyglucose F18 Neuropathology Patients Pet Therapy Positron-Emission Tomography Positrons Presenile dementia X-Ray Computed Tomography glucose metabolism
Content Type	Text
Resource Type	Article

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