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Validity of a Linear Hammett Plot for the Stability of Some Carcinogenic 1-Aryl-3,3-dimethyltriazenes in an Aqueous System
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kolar, George F. Preussmann, Rudolf |
| Copyright Year | 1971 |
| Abstract | The stability of fourteen carcinogenic 1-aryl-3,3-dimethyltriazenes to hydrolysis in 0.15 ᴍ phosphate buffer, pH 7.0, at 37° was determined spectroscopically. The data gave an unexpectedly wide span of half-lives resulting in a linear Hammett plot with a reaction constant, ρ= -4.7. These results are in complete agreement with the currently accepted mechanisms of carcinogenic activity associated with this class of compounds. The rapid liberation of a diazonium cation from the labile triazenes (t½, less than 2 × 102 min) seems to be responsible for the induction of local tumours; however, an enzymic activation is necessary for the systemic carcinogenic activity of the compounds stable to hydrolysis (t½, more than 2 × 102 min). Convincing experimental evidence is thus provided for two different mechanisms of activity which are operative within a single class of chemical carcinogens. |
| Starting Page | 950 |
| Ending Page | 953 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1515/znb-1971-0919 |
| Alternate Webpage(s) | http://zfn.mpdl.mpg.de/data/Reihe_B/26/ZNB-1971-26b-0950.pdf |
| Alternate Webpage(s) | https://www.degruyter.com/downloadpdf/j/znb.1971.26.issue-9/znb-1971-0919/znb-1971-0919.pdf |
| PubMed reference number | 4399256 |
| Alternate Webpage(s) | https://doi.org/10.1515/znb-1971-0919 |
| Journal | Medline |
| Volume Number | 26 |
| Journal | Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
