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Zofenopril and ramipril in patients with left ventricular systolic dysfunction after acute myocardial infarction: A propensity analysis of the Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Borghi, Claudio Omboni, Stefano Novo, Salvatore Vinereanu, Dragoş Ambrosio, Giuseppe A. Ambrosioni, Ettore |
| Copyright Year | 2016 |
| Abstract | INTRODUCTION This was a propensity score analysis of the prospective, randomized, double-blind Survival of Myocardial Infarction Long-term Evaluation (SMILE) 4 study in which one-year treatment with zofenopril 60 mg plus acetylsalicylic acid (ASA) 100 mg gave superior results compared to ramipril 10 mg plus ASA in terms of death or hospitalization for cardiovascular causes in patients with acute myocardial infarction (AMI) complicated by left ventricular dysfunction (LVD). MATERIALS AND METHODS A total of 716 patients of the intention-to-treat population were divided into homogeneous propensity quintiles (Q) using a logistic regression model (QI: best risk profile; QV: worst risk profile). RESULTS Treatment was associated with a similar low rate of major cardiovascular events in any Q. However, the efficacy of zofenopril was better than that of ramipril in QII, QV, and particularly QIII (odds ratio (OR) and 95% confidence interval: 0.43 (0.21-0.87), p<0.05]. This result was primarily attributed to a decrease in the risk of cardiovascular hospitalization, particularly striking in the QIII (OR: 0.40, 0.19-0.85; p<0.05). Mortality rate did not significantly differ between the two treatments in any Q. CONCLUSIONS In the SMILE-4 study the propensity analysis confirmed the efficacy of zofenopril in the prevention of long-term cardiovascular outcomes irrespective of the cardiovascular risk profile of post-AMI patients. |
| Starting Page | 530 |
| Ending Page | 558 |
| Page Count | 29 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27708111v1 |
| Volume Number | 17 |
| Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute myocardial infarction Aspirin Cardiovascular Diseases Cessation of life Confidence Intervals Hospitalization Left ventricular systolic dysfunction Patients Ramipril Ventricular Dysfunction Ventricular Dysfunction, Left zofenopril |
| Content Type | Text |
| Resource Type | Article |
