NDLI: Deletions of N33, STK11 and TP53 Are Involved in the Development of Lymph Node Metastasis in Larynx and Pharynx Carcinomas

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Deletions of N33, STK11 and TP53 Are Involved in the Development of Lymph Node Metastasis in Larynx and Pharynx Carcinomas

Content Provider	Semantic Scholar
Author	Guervós, Marta Alonso Marcos, César Álvarez Hermsen, Mario A. Nuño, Andrés Sampedro Suarez, Carlos Ernesto Llorente, José Luis
Copyright Year	2007
Abstract	BACKGROUND Lymph node metastasis is the mayor cause of mortality in patients with head and neck squamous cell carcinomas (45%). The genetic changes underlying metastasis are still largely unknown and genetic markers to predict lymph node positivity still need to be found. The aim of this study was to search such markers by using Multiplex Ligation-dependent Probe Amplification (MLPA), a semi-quantitative PCR technique to detect gene copy number alterations. METHODS Thirty-seven genes were analysed by MLPA in 34 larynx and 22 pharynx carcinomas. RESULTS Losses of CDKN2A (9p21) and MLH1 (3p22) and gains of CCND1, EMS1 (both at 11q13), RECQL4 and PTP4A3 (both at 8q24) were the most frequent aberrations in both larynx and pharynx carcinomas. Amplifications were detected at EMS1, CCND1 and ERBB2 (17q21). A correlation between loss of N33 (8p22) and poor survival was found (p=0.02). Gain of EMS1 had the same relation with survival but not significant (p=0.08). Lymph node positive tumors presented a specific pattern of genetic alterations, with losses of N33, STK11 (19p13) and TP53 (17p13), the latter especially in larynx tumors. CONCLUSION We propose that these 3 genes might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas.
Starting Page	327
Ending Page	334
Page Count	8
File Format	PDF HTM / HTML
PubMed reference number	4618212
Volume Number	29
Journal	Cellular oncology : the official journal of the International Society for Cellular Oncology
Language	English
Access Restriction	Open
Subject Keyword	11q13 17p13 17q21 19p13 3p22 8q24 9p21 Anatomic Node CTTN wt Allele Copy Number Genetic Markers Goodpasture-antigen-binding protein kinase activity Laryngeal neoplasm Larynx Lymph Node Tissue Lymphadenopathy Multiplex Ligation-Dependent Probe Amplification Patients Pharyngeal Neoplasms Pharyngeal structure RECQL4 gene Reverse Transcriptase Polymerase Chain Reaction STK11 gene Squamous Epithelial Cells Squamous cell carcinoma TUSC3 gene TUSC3 wt Allele chromosome 8p22 lymph node metastases lymph nodes
Content Type	Text
Resource Type	Article

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