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Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ishida, Yasushi Todaka, Kazunari Kuwahara, Itsumi Nakane, Hideyuki Mitsuyama, Yoshio |
| Copyright Year | 1998 |
| Abstract | In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission. |
| Starting Page | 355 |
| Ending Page | 360 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0168-0102(98)00015-7 |
| PubMed reference number | 9678640 |
| Journal | Medline |
| Volume Number | 30 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0168010298000157 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0168010298000157?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0168-0102%2898%2900015-7 |
| Journal | Neuroscience Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
