Relationship between myocardial damage and C-reactive protein levels immediately after onset of acute myocardial infarction.

Content Provider	Semantic Scholar
Author	Kimura, Kohji Kosuge, Masami Ishikawa, Tadao Shimizu, Masami Endo, Tsutomu Hongo, Yoichiro Tochikubo, Osamu Umemura, Satosi
Copyright Year	2001
Abstract	The present study investigated the relationship between myocardial damage and C-reactive protein (CRP) levels, with no increase in creatine kinase (CK) activity, immediately after the onset of acute myocardial infarction (AMI) in 85 patients with their first reperfused anterior AMI without CK elevation on admission and no ischemic events during hospitalization. Patients were classified into those with low levels (<0.3 mg/dl) of CRP (Group L; n=67) and those with high levels (> or =0.3 mg/dl) of CRP (Group H; n=18). Group H had a higher proportion of patients with a history of preinfarction angina (89 vs 55%, p<0.01), especially unstable angina. SigmaST in leads V1-6 on admission ECG was lower in Group H than in Group L (14+/-7 vs 21+/-13 mm, p<0.05). Predischarge left ventriculography showed that the left ventricular global ejection fraction (55+/-11 vs 48+/-10%, p<0.01) and SD/chord at the left anterior descending artery lesion (-1.7+/-0.9 vs -2.3+/-0.9, p<0.01) were better in Group H. Multivariate analysis demonstrated that both CRP on admission (p=0.011) and preinfarction angina (p=0.002) were independently associated with better regional wall motion (SD/chord >-2.0) before discharge. These results suggest that the clinical situation of elevated CRP immediately after onset is associated with less myocardial damage and better left ventricular function in reperfused anterior AMI.
Starting Page	67
Ending Page	70
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/jcj/65/2/65_2_67/_pdf/-char/en
PubMed reference number	11216827v1
Volume Number	65
Issue Number	2
Journal	Japanese circulation journal
Language	English
Access Restriction	Open
Subject Keyword	Acute myocardial infarction Angina Pectoris Angina, Unstable Anterior descending branch of left coronary artery C-reactive protein Cardiomyopathies Cerebral Ventriculography Classification Creatine Kinase Eighty Nine Ejection fraction (procedure) Hospitalization Left Ventricular Function Myocardium Patients Unstable Medical Device Problem mg/dl
Content Type	Text
Resource Type	Article