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Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yao, Jianhua Franaszek, Marek Bitter, Ingmar |
| Copyright Year | 2005 |
| Abstract | BACKGROUND & AIMS The sensitivity of computed tomographic (CT) virtual colonoscopy (CT colonography) for detecting polyps varies widely in recently reported large clinical trials. Our objective was to determine whether a computer program is as sensitive as optical colonoscopy for the detection of adenomatous colonic polyps on CT virtual colonoscopy. METHODS The data set was a cohort of 1186 screening patients at 3 medical centers. All patients underwent same-day virtual and optical colonoscopy. Our enhanced gold standard combined segmental unblinded optical colonoscopy and retrospective identification of precise polyp locations. The data were randomized into separate training (n = 394) and test (n = 792) sets for analysis by a computer-aided polyp detection (CAD) program. RESULTS For the test set, per-polyp and per-patient sensitivities for CAD were both 89.3% (25/28; 95% confidence interval, 71.8%-97.7%) for detecting retrospectively identifiable adenomatous polyps at least 1 cm in size. The false-positive rate was 2.1 (95% confidence interval, 2.0-2.2) false polyps per patient. Both carcinomas were detected by CAD at a false-positive rate of 0.7 per patient; only 1 of 2 was detected by optical colonoscopy before segmental unblinding. At both 8-mm and 10-mm adenoma size thresholds, the per-patient sensitivities of CAD were not significantly different from those of optical colonoscopy before segmental unblinding. CONCLUSIONS The per-patient sensitivity of CT virtual colonoscopy CAD in an asymptomatic screening population is comparable to that of optical colonoscopy for adenomas > or = 8 mm and is generalizable to new CT virtual colonoscopy data. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.viatronix.com/PDFs/AGACAD.pdf |
| PubMed reference number | 16344052v1 |
| Volume Number | 129 |
| Issue Number | 6 |
| Journal | Gastroenterology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenoma Adenomatous Polyposis Coli Adenomatous Polyps Carcinoma Colonic Polyps Computed Tomographic Colonography Computer software Confidence Intervals Patients Subject Unblinding Event Record X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
