The role of ultrasonography in the diagnosis of fetal isolated complete agenesis of the corpus callosum: a long-term prospective study.

Content Provider	Semantic Scholar
Author	Cignini, Pietro D'Emidio, Laura Padula, Francesco Girgenti, Alessandra Battistoni, Silvia Vigna, Roberto Franco, Rodrigo Da Silva Rossetti, Diego Giorlandino, Maurizio Giorlandino, Claudio
Copyright Year	2010
Abstract	OBJECTIVE To evaluate the role of a dedicated neurosonographer in prenatal diagnosis of isolated complete agenesis of the corpus callosum (iCACC) and to asses the postnatal outcome of these infants. METHODS Prospective study between January 2004 to December 2004 at Fetal Maternal Medical Centre 'Artemisia', Rome, Italy. A detailed ultrasound scan was performed in fetuses affected by iCACC by a dedicated fetal neurosonographer (CG). In all cases, magnetic resonance imaging (MRI) within 5 weeks and 13-15 months after birth was performed. A comparison was made between prenatal findings following the ultrasound scan and postnatal MRI. In these cases, a follow-up of 4-years was performed with a neurological evaluation. RESULTS Among 23 cases of ACC diagnosed at our centre in the study period, CACC was diagnosed in 17 fetuses. Two were then excluded due to associated malformations, one was lost at follow-up and one patient opted to terminate her pregnancy. Newborn MRI confirmed the ultrasonographic diagnosis of iCACC in all 13 cases. A regular development was present in 92.3% of prenatally diagnosed iCACC. CONCLUSION A dedicated neurosonographer could diagnose the iCACC with the same accuracy as MRI and in up to 90% of cases the newborn will have a regular development.
Starting Page	013128
Ending Page	013128
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.claudiogiorlandino.it/sites/default/files/ultrasonography.pdf
PubMed reference number	20230313v1
Alternate Webpage(s)	https://doi.org/10.3109/14767051003678101
DOI	10.3109/14767051003678101
Journal	The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Volume Number	23
Issue Number	12
Language	English
Access Restriction	Open
Subject Keyword	Agenesis of corpus callosum Aplasia Cutis Congenita Body of uterus CLCA2 wt Allele Congenital Abnormality Exclusion Fetus Infant, Newborn Magnetic Resonance Imaging Patients Ultrasonography
Content Type	Text
Resource Type	Article