NDLI: Complete chiral symmetry breaking of an amino acid derivative directed by circularly polarized light.

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Complete chiral symmetry breaking of an amino acid derivative directed by circularly polarized light.

Content Provider	Semantic Scholar
Author	Noorduin, Wim L. Bode, Arno A. C. Meijden, Maarten W. Van Der Meekes, Hugo Etteger, Albert F. Van Enckevort, Willem J. P. Van Christianen, Peter C. M. Kaptein, Bernard Kellogg, R. Rasing, Th. Vlieg, Elias
Copyright Year	2009
Abstract	Circularly polarized light (CPL) emitted from star-forming regions is an attractive candidate as a cause of single chirality in nature. It has remained difficult, however, to translate the relatively small chemical effects observed on irradiation of molecular systems with CPL into high enantiomeric excesses. Here we demonstrate that irradiation of a racemic amino acid derivative with CPL leads to a small amount of chiral induction that can be amplified readily to give an enantiopure solid phase. A racemate composed of equal amounts of left- and right-handed crystals in contact with the irradiated solution is converted completely into crystals of single-handedness through abrasive grinding when racemization is effected in the solution. The rotation sense of the CPL fully determines the handedness of the final solid state. These findings illustrate the potential effectiveness of CPL in the control of molecular asymmetry, which is relevant for the origin of the single chirality inherent to many biological molecules.
File Format	PDF HTM / HTML
DOI	10.1038/nchem.416
PubMed reference number	21124360
Journal	Medline
Volume Number	1
Issue Number	9
Alternate Webpage(s)	https://www.rug.nl/research/portal/files/14467085/2009NatChemNoorduin.pdf
Alternate Webpage(s)	https://www.rug.nl/research/portal/files/14467084/2009NatChemNoorduinSupp.pdf
Alternate Webpage(s)	https://pure.rug.nl/ws/files/14467084/2009NatChemNoorduinSupp.pdf
Alternate Webpage(s)	https://doi.org/10.1038/nchem.416
Journal	Nature chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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