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Post-prandial endothelial dysfunction is ameliorated following weight loss in obese premenopausal women
| Content Provider | Semantic Scholar |
|---|---|
| Author | Haspicova, Marcela Milek, David Šiklová-Vítková, Michaela Wedellová, Zuzana Hejnova, Jindriska Bajzova, Magda Štich, Vladimír Polák, Jan |
| Copyright Year | 2011 |
| Abstract | BACKGROUND Endothelial dysfunction and postprandial hyperglycemia represent independent risk factors for cardiovascular diseases. Obesity is connected with endothelial impairments; however, it is unclear whether weight loss can modify endothelial function during the postprandial period. The aim of this study was to evaluate endothelial response (post-ischemic forearm blood flow, PIFBF) in a fasted state and following ingestion of 75 g glucose before and after very low caloric diet (VLCD). MATERIAL/METHODS 40 obese premenopausal women (age 39.6 ± 7.8 years, BMI 34.3 ± 3.2 kg/m2) participated in 4-week very low caloric diet (VLCD, 800 kcal/day). Before and after VLCD, the baseline blood flow and PIFBF were measured using a mercury strain gauge plethysmography in fasting state as well as 1 hour after ingestion of 75 g glucose. RESULTS Dietary intervention resulted in a 7% weight loss (p<0.05) and a decrease in insulin resistance index HOMA-IR (2.44 ± 1.25 vs. 1.66 ± 0.81, p<0.05). Before VLCD intervention, PIFBF following oral glucose challenge decreased by 8.2 ± 9.1 ml/min/100 g tissue, while after weight loss identical stimulus increased PIFBF by 4.2 ± 8.9 ml/min/100 g tissue (p<0.05). Plasma ICAM-1 and VCAM-1 decreased by 8% and 10%, respectively, throughout the study. CONCLUSIONS Postprandial endothelial dysfunction is ameliorated following weight loss in obese women. This finding demonstrates the beneficial effects of weight reduction on atherosclerosis risk. |
| Starting Page | CR634 |
| Ending Page | CR639 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/b7/59/medscimonit-17-11-cr634.PMC3539500.pdf |
| PubMed reference number | 22037742v1 |
| Volume Number | 17 |
| Journal | Medical science monitor : international medical journal of experimental and clinical research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Atherosclerosis Cardiovascular Diseases Disease Endothelial Growth Factors Endothelium Fat-Restricted Diet Glucose How Much Distress Weight Loss Hyperglycemia Insulin Resistance Kilogram Per Square Meter Obesity Plethysmography Reducing diet Vascular Cell Adhesion Molecule-1 kilocalorie |
| Content Type | Text |
| Resource Type | Article |
